Though present in the fetus, it is seldom the cause of erythroblastosis fetalis or of transfusion reactions. The Lu(a−b+) phenotype is the most common in all populations, whereas the Lu(a−b−) phenotype is uncommon. The phenotypes Lu(a+b−) and Lu(a+b+) are found at various frequencies within populations. The antigens Aua and Aub, known as the Auberger antigens, were once thought to make up a separate blood group but were later shown to be Lutheran antigens arising from variations in the BCAM gene. The system is based on the expression of two codominant alleles, designated Lua and Lub. As with most of our species’ biological oddities, scientists believe that Rh-negative blood initially resulted from a DNA mutation that evidently served some sort of evolutionary purpose that. For more about plasma donation, visit the plasma donation facts. The universal plasma donor has Type AB blood. Īll of these antigens arise from variations in a gene called BCAM (basal cell adhesion molecule). The universal red cell donor has Type O negative blood. The Lutheran antigen systems is a classification of human blood based on the presence of substances called Lutheran antigens on the surfaces of red blood cells. Crawford worked at the Serum Exchange of the Children's Hospital of Philadelphia, where, in 1962, she discovered that she was one of a few people in the world with the rare blood type Lu (a−b−) and that her blood might be donated to a patient in Great Britain.
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